Inositol phospholipids are important precursors for signaling molecules involved in a variety of cellular processes. Phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is the most studied of these lipids. Conditional depletion of cellular PI(4,5)P2 has already been accomplished using expression of a Pleckstrin Homology Domain, which binds specifically to these molecules, and will sequester them when overexpressed. This paper demonstrates a chemical alternative to achieve this conditional knock-down of PI(4,5)P2. Their final product is a bis-urea, bis-boronic acid molecule, taking advantage of already-known phosphate - interacting properties of some of these molecules.
No comments:
Post a Comment