Bacteriophages and Viruses as a Support for Organic Synthesis and Combinatorial Chemistry

We learned about DNA-encoded small molecules. This is a review article that starts with that idea, but makes the DNA "encoding" in a "living" organism, as oppsed to attaching the small molecule to the DNA itself. Since you can't really encode a small molecule in DNA, but rather have a sequence-specific tag for your unique molecule, the DNA doesn't even have to encode a functional protein, like i showed with the phage display on tuesday. Combinatorial chemistry seeks to produce huge variants of chemicals and there is probably an equally huge possibility for DNA sequences...Now how to track each one...and think of selections for your chemistry, and amplify your 'barcode'.