Metallodrugs were a topic of discussion during the DNA and RNA small molecule lectures. The use of Cisplatin as an anticancer treatment has been well established, but characterization of RNA-Pt formation has not been previously performed. This paper discusses toxicity and induction of cell death through cisplatin, intracellular concentrations, as well as accumulation of Pt within different nucleic acids. They found that more Pt is associated with RNA than with DNA and developed structural models of the RNA-PT adducts. Specifically, there was a large accumulation of Pt within the eukaryotic ribosome, suggesting binding pockets on rRNA. Interaction of the Pt with RNA (mRNA
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