DNA-encoded chemical library is a technology that advances the identification of ligands and small molecules for protein targets. The use of a DNA-encoded library makes the connection between genotype and pheontype easier to identify through amplification of the DNA "barcode". This review discussed the growth of the technology and enhanced methods that have been developed. Applications through the years are also presented.
Maybe this paper can be used the next time the class is taught. It helps put the papers we read into a broader context.
ReplyDeleteDNA encoded library (DEL) is a new screening platform commonly used to discover small-molecules that interfere with the activity of pharmaceutically relevant proteins. DNA-encoded chemical libraries are hybrid-type collections of combinatorial organic molecules, individually coupled to distinctive DNA fragments. DNA Encoded Library
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