Reversible Covalent Chemistries Compatible with the Principles of Constitutional Dynamic Chemistry: New Reactions to Create More Diversity

While preparing my slides on unnatural nucleotides, I came across the idea of dynamic combinatorial chemistry. Essentially, one creates a dynamic combinatorial library, where individual components are reversibly bonding to one another creating interchanging products under thermodynamic control. Upon addition of a target molecule, the equilibrium changes based on Le Chatalier's rules, enriching the multimers with the highest affinity to the target.

This review covers some of the best examples of reactions that are suited for DCC.