Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance in Staphylococcus aureus (MRSA)

This article focuses on using alkyl boronic acids as inhibitors of Penicillin-Binding Proteins (PBPs) which can be used aganist β-Lactam resistant pathogens . The authors have identified alkyl boronic acids that are active against methicillin-resistant S. aureus (MRSA). This article explains how the spread of antibiotic resistance by bacterial pathogens is increasing and how there is a need to find the next active family of antimicrobials.