Wednesday, August 3, 2011

High-Density, Multiplexed Patterning of Cells at Single-Cell Resolution for Tissue Engineering and Other Applications

The DNA encoded 2D and 3D patterning of cells was recently reported in Angewandte Chemie. The authors used the biotinylation of cell surface proteins followed by binding to streptavidin-conjugated oligonucleotides. This and other DNA-cell labeling methodologies had previously been reported. I am surprised they didn't do a cell surface display of streptavidin and used biotinylated DNA. I am also wondering if that could be done in a light-activated fashion...

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