This blog supports the CH795 Special Topics in Chemistry courses taught by Dr. Gavin Williams and Dr. Alex Deiters at North Carolina State University. Please include an illustrative figure when you post a blog entry.
Wednesday, August 3, 2011
High-Density, Multiplexed Patterning of Cells at Single-Cell Resolution for Tissue Engineering and Other Applications
The DNA encoded 2D and 3D patterning of cells was recently reported in Angewandte Chemie. The authors used the biotinylation of cell surface proteins followed by binding to streptavidin-conjugated oligonucleotides. This and other DNA-cell labeling methodologies had previously been reported. I am surprised they didn't do a cell surface display of streptavidin and used biotinylated DNA. I am also wondering if that could be done in a light-activated fashion...
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