This article describes research that has been done to design novel ligands for Class B G protein-coupled receptors. The activation and binding domains are fused using 'click chemistry.' An optimized ligand containing unnatural amino acids bound in the nanomolar range and was able to activate its intended receptor with high specificity.
Here is the link to the actual article: http://pubs.acs.org/doi/full/10.1021/ja200160s
ReplyDeleteHowever, I have no idea why the authors are emphasizing the 'click' reaction here. They could have more easily made a standard peptide bond in their synthesis and then screened the library for inhibitors.