Epigenetics is the study of gene expression without the change in DNA sequence. Histones which are proteins wrapped around DNA play an important role in regulating gene activity. This paper talks about various synthetic strategies to site specifically modify histones which regulate the structure and function of the chromatin. Most studies focus on alterations on DNA to control gene regulation however; this paper gives us a wider understanding in gene regulation through histone modifications and epigenetics
There are some great techniques mentioned in this paper. The last section before the conclusion mentions using unnatural amino acids to modify histones, which is pretty cool.
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