In this paper, the authors show how they use a N-terminal Sulfanylethylanilide peptide linker to improve Native Chemical Ligation (NCL) process. They reported that this N-Sulfanylethylanilide moiety can efficiently substitute the thioester intermediate usually formed during NCL. They also report the first one-pot, four peptide components coupling under kinetic conditions.
This is quite promising for the synthesis of large proteins.
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