Restricted Lateral Diffusion of Luteinizing Hormone Receptors in Membrane Microdomains

This Journal of Biological Chemistry paper expands on the prior discovery that hormone receptors aggregate upon binding of hormones. The authors used gold nano-particles to image individual receptors and discover that they are contained to a small portion of the membrane during activation. Point mutation to  disturb membrane anchoring was also examined to determine that without membrane anchoring, compartmentalization did not occur.