In this paper, Musumeci and co-workers found new miR-15a/16 targets responsible for tumor promoting activity in non-neoplastic associated fibroblasts. They have shown miR-15a/16 are downregulated in fibroblast cells that are surrounded by tumor cells. Downregulation of these microRNAs induced the expression of growth factor FGF-2 which promotes tumor growth and progression via microenvironment cross talk. I found this article interesting that microRNAs are involved in cell-cell interactions.
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