I was at an RNA symposium this weekend and Qi Zhang presented an interesting structural analysis of the telomerase RNA. This article discusses how the structure of the RNA component of telomerase core domain is important for template recognition. The core domain has a 39 degree angle of motion that correlates well with moving across the template DNA during telomere extension. It is a nice example of using structural information to understand the mechanism of action for biologically relevant enzymes. Additionally, the structural data could be used to develop specific SM inhibitors as we previously learned.
Monday, October 24, 2011
Architecture of human telomerase RNA
I was at an RNA symposium this weekend and Qi Zhang presented an interesting structural analysis of the telomerase RNA. This article discusses how the structure of the RNA component of telomerase core domain is important for template recognition. The core domain has a 39 degree angle of motion that correlates well with moving across the template DNA during telomere extension. It is a nice example of using structural information to understand the mechanism of action for biologically relevant enzymes. Additionally, the structural data could be used to develop specific SM inhibitors as we previously learned.
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