This review discusses the use of controlling proteins through light or small molecule regulation, and how those tools can be used to study cellular migration. It goes over many topics we have discussed in class: chemical genetics approaches, protein dimerization/activation with SM, caging molecules, fluorescent reporters, sensors/switches, etc. I think it is a cool overview that links the material in a meaningful example.
NOTE: Contains shout-outs to Deiters for photochemical protein control, photocaged rapamycin, and engineered kinases.
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