This blog supports the CH795 Special Topics in Chemistry courses taught by Dr. Gavin Williams and Dr. Alex Deiters at North Carolina State University. Please include an illustrative figure when you post a blog entry.
Friday, September 30, 2011
Beyond directed evolution—semi-rational protein engineering and design
This review examines a computational approach to rational design. Highlighting recent engineering and design examples, while emphasizing the efficiency in using small highly functional libraries. These stated techniques rely on a posteriori structural and mechanistic data, yet are thought to enhance the probability of finding viable targets that catalyze biochemical reactions.
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