Synthetic chromosome arms function in yeast and generate phenotypic diversity by design

This paper describes a logical extension of the work pioneered by Craig Venter in creating an organism with a synthetic genome. However, while Venter's work focused on Mycoplasma genitalium because of the small size of its genome, most industrial fermentation processes use yeast or E. coli, as their metabolic pathways are well characterized. In this paper, the authors begin their work to create a synthetic yeast variant. This genome will be minimalized and contain an inducible evolution system.