Exploiting the P-1 Pocket of BRCT Domains Toward a Structure

This paper describes the discovery of a potent inhibitor of the protein interaction BRCT - BRCA1 involved in breast cancer. They synthesized different peptide analogs via solid phase chemistry and used an homology model to explore the binding pocket of the target protein interaction. Also, they did a streptavidin pulldown assay to evaluate the relative affinity of their optimized inhibitor for BRCT-BRCA1.

This is interesting and show that even some homology model can be a precious help in designing efficient small molecules/peptide mimics inhibitors.