This blog supports the CH795 Special Topics in Chemistry courses taught by Dr. Gavin Williams and Dr. Alex Deiters at North Carolina State University. Please include an illustrative figure when you post a blog entry.
Monday, September 12, 2011
Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics.
In the search to create de novo protein catalysts, catalytic antibodies (abzymes) have been shown to be very efficient. CAbs are primarily made by inducing an immune response with a hapten that resembles the transition state of a reaction. This selection scheme allows for a protein environment that thermodynamiclly stabilizes the TS, but is not necessarily favored kinetically. This paper describes the generation of "reactibodies", which are selected for chemical reactivity rather than ground state binding by forming a irreversible covalent bond.
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